Clinical Studies
Clinical Studies
Clinical Studies
We are Experts in Everything Microbiome.
We are Experts in Everything Microbiome.
We are Experts in Everything Microbiome.
When your team is pushing the boundaries of skincare innovation and seeking to unlock deeper insights into your products’ effects on the skin’s microbiome, we are here to support your R&D efforts. Our specialized expertise in microbiome research enables us to design and execute comprehensive In-Vivo studies that reveal how cosmetic raw materials and final formulations interact with and influence the skin’s microbial ecosystem.
These studies provide critical, scientifically-backed data to drive breakthrough product development, refine formulations, and validate microbiome-focused claims. By integrating cutting-edge research with innovative testing methods, we help you stay at the forefront of microbiome science and accelerate your path to breakthrough skincare solutions.
When your team is pushing the boundaries of skincare innovation and seeking to unlock deeper insights into your products’ effects on the skin’s microbiome, we are here to support your R&D efforts. Our specialized expertise in microbiome research enables us to design and execute comprehensive In-Vivo studies that reveal how cosmetic raw materials and final formulations interact with and influence the skin’s microbial ecosystem.
These studies provide critical, scientifically-backed data to drive breakthrough product development, refine formulations, and validate microbiome-focused claims. By integrating cutting-edge research with innovative testing methods, we help you stay at the forefront of microbiome science and accelerate your path to breakthrough skincare solutions.
When your team is pushing the boundaries of skincare innovation and seeking to unlock deeper insights into your products’ effects on the skin’s microbiome, we are here to support your R&D efforts. Our specialized expertise in microbiome research enables us to design and execute comprehensive In-Vivo studies that reveal how cosmetic raw materials and final formulations interact with and influence the skin’s microbial ecosystem.
These studies provide critical, scientifically-backed data to drive breakthrough product development, refine formulations, and validate microbiome-focused claims. By integrating cutting-edge research with innovative testing methods, we help you stay at the forefront of microbiome science and accelerate your path to breakthrough skincare solutions.
Our Methodologies & Techniques for Microbiome Research
Our Methodologies & Techniques for Microbiome Research
Our Methodologies & Techniques for Microbiome Research
Advanced Recruitment Platform
Volunteer recruitment strategies to ensure diverse and representative sampling aligned with study objectives.
Advanced Recruitment Platform
Volunteer recruitment strategies to ensure diverse and representative sampling aligned with study objectives.
Advanced Recruitment Platform
Volunteer recruitment strategies to ensure diverse and representative sampling aligned with study objectives.
State-of-the-Art Sequencing Technology
Deployment of HiFi sequencing technology on the PacBio Revio platform, providing long-read, highly accurate sequencing of bacterial and fungal genomes.
State-of-the-Art Sequencing Technology
Deployment of HiFi sequencing technology on the PacBio Revio platform, providing long-read, highly accurate sequencing of bacterial and fungal genomes.
State-of-the-Art Sequencing Technology
Deployment of HiFi sequencing technology on the PacBio Revio platform, providing long-read, highly accurate sequencing of bacterial and fungal genomes.
Precision Sampling Protocols
Dedicated sampling and initial assessment protocols performed by trained clinical professionals, utilizing specialized sampling methodologies.
Precision Sampling Protocols
Dedicated sampling and initial assessment protocols performed by trained clinical professionals, utilizing specialized sampling methodologies.
Precision Sampling Protocols
Dedicated sampling and initial assessment protocols performed by trained clinical professionals, utilizing specialized sampling methodologies.
Advanced Bioinformatics Pipelines
Comprehensive bioinformatics pipelines capable of detailed taxonomic profiling and microbial community analysis.
Advanced Bioinformatics Pipelines
Comprehensive bioinformatics pipelines capable of detailed taxonomic profiling and microbial community analysis.
Advanced Bioinformatics Pipelines
Comprehensive bioinformatics pipelines capable of detailed taxonomic profiling and microbial community analysis.
High-Quality DNA Extraction
High-quality DNA extraction techniques that optimize DNA yield and integrity for reliable sequencing.
High-Quality DNA Extraction
High-quality DNA extraction techniques that optimize DNA yield and integrity for reliable sequencing.
High-Quality DNA Extraction
High-quality DNA extraction techniques that optimize DNA yield and integrity for reliable sequencing.
Robust Diversity & Statistical Tools
Advanced statistical and diversity analysis tools to evaluate microbial richness, evenness, and community dynamics over time.
Robust Diversity & Statistical Tools
Advanced statistical and diversity analysis tools to evaluate microbial richness, evenness, and community dynamics over time.
Robust Diversity & Statistical Tools
Advanced statistical and diversity analysis tools to evaluate microbial richness, evenness, and community dynamics over time.
Stringent DNA Quality Control
Rigorous DNA quality control processes, ensuring samples meet the highest standards for sequencing accuracy.
Stringent DNA Quality Control
Rigorous DNA quality control processes, ensuring samples meet the highest standards for sequencing accuracy.
Stringent DNA Quality Control
Rigorous DNA quality control processes, ensuring samples meet the highest standards for sequencing accuracy.
In-Depth Community Comparison
Integration of weighted and unweighted beta diversity analysis for in-depth comparison of microbial populations across samples.
In-Depth Community Comparison
Integration of weighted and unweighted beta diversity analysis for in-depth comparison of microbial populations across samples.
In-Depth Community Comparison
Integration of weighted and unweighted beta diversity analysis for in-depth comparison of microbial populations across samples.
Targeted Library Preparation
Sophisticated amplicon library preparation workflows, enabling targeted sequencing of key microbial regions.
Targeted Library Preparation
Sophisticated amplicon library preparation workflows, enabling targeted sequencing of key microbial regions.
Targeted Library Preparation
Sophisticated amplicon library preparation workflows, enabling targeted sequencing of key microbial regions.
Data-Driven Insights & Conclusions
Results supported by the latest microbiome research technologies, delivering actionable insights for product development.
Data-Driven Insights & Conclusions
Results supported by the latest microbiome research technologies, delivering actionable insights for product development.
Data-Driven Insights & Conclusions
Results supported by the latest microbiome research technologies, delivering actionable insights for product development.
We Help You Navigate the Balance Between Cost, Data and Insights
In-Vivo studies can vary significantly in cost depending on factors such as study design, duration, sample size, and sampling points. We collaborate with you to craft the most effective and efficient research strategies tailored to your product’s unique innovation goals, aligning with regulatory requirements in your target markets, the desired biological effects, and the potential for breakthrough claims.
Our approach goes beyond raw data — we interpret and contextualize the results, transforming complex findings into clear, scientifically robust insights that empower you to make innovative, evidence-backed claims and accelerate product development.
We Help You Navigate the Balance Between Cost, Data and Insights
In-Vivo studies can vary significantly in cost depending on factors such as study design, duration, sample size, and sampling points. We collaborate with you to craft the most effective and efficient research strategies tailored to your product’s unique innovation goals, aligning with regulatory requirements in your target markets, the desired biological effects, and the potential for breakthrough claims.
Our approach goes beyond raw data — we interpret and contextualize the results, transforming complex findings into clear, scientifically robust insights that empower you to make innovative, evidence-backed claims and accelerate product development.
We Help You Navigate the Balance Between Cost, Data and Insights
In-Vivo studies can vary significantly in cost depending on factors such as study design, duration, sample size, and sampling points. We collaborate with you to craft the most effective and efficient research strategies tailored to your product’s unique innovation goals, aligning with regulatory requirements in your target markets, the desired biological effects, and the potential for breakthrough claims.
Our approach goes beyond raw data — we interpret and contextualize the results, transforming complex findings into clear, scientifically robust insights that empower you to make innovative, evidence-backed claims and accelerate product development.
We Walk You Through All The Steps of a Robust In-Vivo Study
Volunteer Recruitment – Identify study participants according to the needs and expected outcomes of the study. Ensure diverse representation that fits the criteria required for the study.
Volunteer Instruction, Evaluation and Initial Sampling – Inform the volunteers about the instructions of use of the product and conduct initial sample collection to establish a baseline for microbiome analysis. Volunteers will come to our facilities over the course of the study at the agreed time points to be sampled by clinical professionals.
DNA Isolation from samples – Extract the DNA from the collected samples from each volunteer at each time point to obtain the genetic material needed for sequencing and further analysis.
DNA Sample Quality Control – Check the quality of the isolated DNA to ensure its suitable for sequencing. By having clinical professionals conduct the swabbing/sampling the risk of inadequate or degraded DNA is greatly minimized.
Amplicon Library Preparation – Prepare a library of amplicons (DNA fragments) for the targeted regions of interest, facilitating the sequencing process and ensuring DNA is in the correct format.
Amplicon Metagenomics Sequencing – Sequence the DNA using HiFi sequencing on Pacbio Revio platform focusing on 16S rRNA and ITS regions, for bacteria and fungi respectively. By doing so we identify and quantify the microbial species present in the samples.
Bioinformatics Analysis – Conduct taxonomic profiling by classifying bacteria and fungi in various taxonomic levels. Understand which microorganisms are present and at what relative abundance in each time point of the study.
Alpha Diversity – Assess the variety (richness) and relative abundance (evenness) of species in each sample, Evaluate the complexity of the microbial community through the different timepoints of the study.
Statistical Analysis – Apply statistical methods to analyse data and identify significant trends and differences in the microbiome composition.
Beta Diversity (Weighted and Unweighted) – Compare microbial communities between samples to see how similar or different they are. Identify the patters and changes over time.
Conclusions – Assess all the above parameters and conclude as to the desired action of the product being tested.
Contact us today for a consultation
Volunteer Recruitment – Identify study participants according to the needs and expected outcomes of the study. Ensure diverse representation that fits the criteria required for the study.
Volunteer Instruction, Evaluation and Initial Sampling – Inform the volunteers about the instructions of use of the product and conduct initial sample collection to establish a baseline for microbiome analysis. Volunteers will come to our facilities over the course of the study at the agreed time points to be sampled by clinical professionals.
DNA Isolation from samples – Extract the DNA from the collected samples from each volunteer at each time point to obtain the genetic material needed for sequencing and further analysis.
DNA Sample Quality Control – Check the quality of the isolated DNA to ensure its suitable for sequencing. By having clinical professionals conduct the swabbing/sampling the risk of inadequate or degraded DNA is greatly minimized.
Amplicon Library Preparation – Prepare a library of amplicons (DNA fragments) for the targeted regions of interest, facilitating the sequencing process and ensuring DNA is in the correct format.
Amplicon Metagenomics Sequencing – Sequence the DNA using HiFi sequencing on Pacbio Revio platform focusing on 16S rRNA and ITS regions, for bacteria and fungi respectively. By doing so we identify and quantify the microbial species present in the samples.
Bioinformatics Analysis – Conduct taxonomic profiling by classifying bacteria and fungi in various taxonomic levels. Understand which microorganisms are present and at what relative abundance in each time point of the study.
Alpha Diversity – Assess the variety (richness) and relative abundance (evenness) of species in each sample, Evaluate the complexity of the microbial community through the different timepoints of the study.
Statistical Analysis – Apply statistical methods to analyse data and identify significant trends and differences in the microbiome composition.
Beta Diversity (Weighted and Unweighted) – Compare microbial communities between samples to see how similar or different they are. Identify the patters and changes over time.
Conclusions – Assess all the above parameters and conclude as to the desired action of the product being tested.
Contact us today for a consultation
We Walk You Through All The Steps of a Robust In-Vivo Study
Volunteer Recruitment – Identify study participants according to the needs and expected outcomes of the study. Ensure diverse representation that fits the criteria required for the study.
Volunteer Instruction, Evaluation and Initial Sampling – Inform the volunteers about the instructions of use of the product and conduct initial sample collection to establish a baseline for microbiome analysis. Volunteers will come to our facilities over the course of the study at the agreed time points to be sampled by clinical professionals.
DNA Isolation from samples – Extract the DNA from the collected samples from each volunteer at each time point to obtain the genetic material needed for sequencing and further analysis.
DNA Sample Quality Control – Check the quality of the isolated DNA to ensure its suitable for sequencing. By having clinical professionals conduct the swabbing/sampling the risk of inadequate or degraded DNA is greatly minimized.
Amplicon Library Preparation – Prepare a library of amplicons (DNA fragments) for the targeted regions of interest, facilitating the sequencing process and ensuring DNA is in the correct format.
Amplicon Metagenomics Sequencing – Sequence the DNA using HiFi sequencing on Pacbio Revio platform focusing on 16S rRNA and ITS regions, for bacteria and fungi respectively. By doing so we identify and quantify the microbial species present in the samples.
Bioinformatics Analysis – Conduct taxonomic profiling by classifying bacteria and fungi in various taxonomic levels. Understand which microorganisms are present and at what relative abundance in each time point of the study.
Alpha Diversity – Assess the variety (richness) and relative abundance (evenness) of species in each sample, Evaluate the complexity of the microbial community through the different timepoints of the study.
Statistical Analysis – Apply statistical methods to analyse data and identify significant trends and differences in the microbiome composition.
Beta Diversity (Weighted and Unweighted) – Compare microbial communities between samples to see how similar or different they are. Identify the patters and changes over time.
Conclusions – Assess all the above parameters and conclude as to the desired action of the product being tested.
Contact us today for a consultation
Volunteer recruitment from our database of 1,500+ individuals
Our database of over 1,500 volunteers enables us to precisely select the ideal participants for your study. Each volunteer has been personally interviewed by our in-house dermatologist and categorized based on skin type, medical history, and skincare habits. All data is anonymized in compliance with GDPR regulations, ensuring privacy and non-bias in selection.
This allows us to confidently recruit the most suitable participants, tailored to the target audience of your product, ensuring your In-Vivo studies produce relevant and impactful results.
Volunteer recruitment from our database of 1,500+ individuals
Our database of over 1,500 volunteers enables us to precisely select the ideal participants for your study. Each volunteer has been personally interviewed by our in-house dermatologist and categorized based on skin type, medical history, and skincare habits. All data is anonymized in compliance with GDPR regulations, ensuring privacy and non-bias in selection.
This allows us to confidently recruit the most suitable participants, tailored to the target audience of your product, ensuring your In-Vivo studies produce relevant and impactful results.
Volunteer recruitment from our database of 1,500+ individuals
Our database of over 1,500 volunteers enables us to precisely select the ideal participants for your study. Each volunteer has been personally interviewed by our in-house dermatologist and categorized based on skin type, medical history, and skincare habits. All data is anonymized in compliance with GDPR regulations, ensuring privacy and non-bias in selection.
This allows us to confidently recruit the most suitable participants, tailored to the target audience of your product, ensuring your In-Vivo studies produce relevant and impactful results.
FAQs related to the In-Vivo Studies
What is the process for selecting and recruiting volunteers for the In-Vivo study?
How do you ensure the accuracy of microbiome analysis during sampling?
What technologies do you use for sequencing microbial DNA?
How do you interpret the data collected from the study?
How do your results support product claims or development?
What is the process for selecting and recruiting volunteers for the In-Vivo study?
How do you ensure the accuracy of microbiome analysis during sampling?
What technologies do you use for sequencing microbial DNA?
How do you interpret the data collected from the study?
How do your results support product claims or development?
What is the process for selecting and recruiting volunteers for the In-Vivo study?
How do you ensure the accuracy of microbiome analysis during sampling?
What technologies do you use for sequencing microbial DNA?
How do you interpret the data collected from the study?
How do your results support product claims or development?
What our clients say
“KIND TO BIOME provides us with the assurance we need to know that our products are friendly to the microbiome of their target area. Whether we are formulating for babies, for the intimate area or the body, KIND TO BIOME offers us the solutions that are best tailored to our products and a certification we can rely on.”
Damien Tackney
Regulatory Officer
“The ability to carry a third party verified mark of approval on your skincare products, such as KIND TO BIOME, is the gold-standard for us and our customers. The future of skincare is rooted in skin health, and KIND TO BIOME are at the forefront of supporting that movement with accountability and transparency.”
Flo Glendenning
VP of Product & Sustainability
What our clients say
“KIND TO BIOME provides us with the assurance we need to know that our products are friendly to the microbiome of their target area. Whether we are formulating for babies, for the intimate area or the body, KIND TO BIOME offers us the solutions that are best tailored to our products and a certification we can rely on.”
Damien Tackney
Regulatory Officer
“KIND TO BIOME provided invaluable insights into understanding the microbiome and assisted us in formulating strategies around effective protocols. We utilized a combination of In Vitro, Ex Vivo, and In Vivo studies to achieve comprehensive results.”
John Milligan
VP R&D
“KIND TO BIOME provides us with the assurance we need to know that our products are friendly to the microbiome of their target area. Whether we are formulating for babies, for the intimate area or the body, KIND TO BIOME offers us the solutions that are best tailored to our products and a certification we can rely on.”
Damien Tackney
Regulatory Officer
What our clients say
“KIND TO BIOME provides us with the assurance we need to know that our products are friendly to the microbiome of their target area. Whether we are formulating for babies, for the intimate area or the body, KIND TO BIOME offers us the solutions that are best tailored to our products and a certification we can rely on.”
Damien Tackney
Regulatory Officer
“The ability to carry a third party verified mark of approval on your skincare products, such as KIND TO BIOME, is the gold-standard for us and our customers. The future of skincare is rooted in skin health, and KIND TO BIOME are at the forefront of supporting that movement with accountability and transparency.”
Flo Glendenning
VP of Product & Sustainability